Entity Details

Primary name PTPN11
Entity type gene
Source Source Link

Details

PrimaryID5781
RefseqGeneNG_007459
SymbolPTPN11
Nameprotein tyrosine phosphatase non-receptor type 11
Chromosome12
Location12q24.13
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsPTN11_HUMAN

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000187 obsolete activation of MAPK activity
GO:0001784 phosphotyrosine residue binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0005158 insulin receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006641 triglyceride metabolic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007507 heart development
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009755 hormone-mediated signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021697 cerebellar cortex formation
GO:0030159 signaling receptor complex adaptor activity
GO:0030168 platelet activation
GO:0030220 platelet formation
GO:0030971 receptor tyrosine kinase binding
GO:0031295 T cell costimulation
GO:0031748 D1 dopamine receptor binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0032528 microvillus organization
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035264 multicellular organism growth
GO:0035265 organ growth
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035855 megakaryocyte development
GO:0036302 atrioventricular canal development
GO:0038127 ERBB signaling pathway
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0043254 regulation of protein-containing complex assembly
GO:0043274 phospholipase binding
GO:0043560 insulin receptor substrate binding
GO:0044853 plasma membrane raft
GO:0045296 cadherin binding
GO:0045778 positive regulation of ossification
GO:0045931 positive regulation of mitotic cell cycle
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046676 negative regulation of insulin secretion
GO:0046825 regulation of protein export from nucleus
GO:0046887 positive regulation of hormone secretion
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048609 multicellular organismal reproductive process
GO:0048659 smooth muscle cell proliferation
GO:0048806 genitalia development
GO:0048839 inner ear development
GO:0048873 homeostasis of number of cells within a tissue
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0051428 peptide hormone receptor binding
GO:0051463 negative regulation of cortisol secretion
GO:0051894 positive regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0060020 Bergmann glial cell differentiation
GO:0060125 negative regulation of growth hormone secretion
GO:0060325 face morphogenesis
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0061582 intestinal epithelial cell migration
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071260 cellular response to mechanical stimulus
GO:0071345 cellular response to cytokine stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1904385 cellular response to angiotensin
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990782 protein tyrosine kinase binding

Diseases

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Interactions

279 interactions

InteractorPartnerSourcesPublicationsLink
PTPN11GRB2BioGRID, HPRD, IntAct10080542 10212213 10747947 12531430 12577067 16371368 19380743 20473329 21706016 28514442 31585087 31980649 7523381 7534299 8041791 8647120 8702859 8959326 8995399 9254654 9361008 9362449 9632781 9660791 9824671 details
PTPN11GAB1BioGRID, HPRD, IntAct, MINT10068651 10871282 11134009 11323411 11453982 11940581 12855672 14665621 14701753 14982882 15574420 20308328 20473329 23612964 24728074 24935154 9632795 9658397 9804835 details
PTPN11METBioGRID, HPRD, IntAct, MINT18579758 24728074 8662733 details
PTPN11PECAM1BioGRID, HPRD, MINT10350061 10704309 10801826 20723025 9054388 9312087 9774457 details
PTPN11SLAMF1BioGRID, HPRD, MINT11313386 11689425 11806999 details
PTPN11FRS2BioGRID, HPRD, IntAct, MINT10650943 11360177 11447289 12974390 16573649 22974441 25159185 29997244 9632781 details
PTPN11NEBBioGRID, IntAct23414517 details
PTPN11EPHA1BioGRID, MINT28065597 details
PTPN11SIRPABioGRID, HPRD, IntAct10962556 15888547 19299420 20473329 8943344 details
PTPN11JAK1BioGRID, HPRD11036942 12270932 12403768 8995399 9794795 details
PTPN11JAK2BioGRID, HPRD7559603 8639815 8912646 8995399 9442080 details
PTPN11IL6STBioGRID, HPRD10777583 10946280 12403768 9195977 9388212 9794795 details
PTPN11PIK3R1BioGRID, HPRD10962556 11593409 16371368 26839216 8647120 9361008 9565634 9632795 9660791 9886492 9918857 details
PTPN11GHRBioGRID, HPRD10976913 9442080 9632636 details
PTPN11SIGLEC12HPRD11328818 details
PTPN11ERBB2BioGRID, HPRD, MINT16273093 16729043 22973453 28065597 8959326 9756944 details
PTPN11GAB2BioGRID, HPRD, IntAct, MINT10068651 10391903 10871282 11287610 11334882 11782427 11812650 12135708 14982882 15170389 15356145 16253990 16371368 19172738 19909739 26839216 9660791 details
PTPN11CAV1BioGRID, HPRD, MINT12176037 24632723 25672415 details
PTPN11CSF2RBBioGRID, HPRD, MINT15194700 9162089 9254654 9973406 details
PTPN11LEPRBioGRID, HPRD, MINT11018044 11342028 9600917 details
PTPN11ARBioGRID, IntAct24728074 details
PTPN11TLK1BioGRID, IntAct27229929 32296183 details
PTPN11PTK7BioGRID, MINT28065597 details
PTPN11PTPN11BioGRID27432908 9632795 9847309 details
PTPN11BEX1BioGRID27229929 details
PTPN11STAT1BioGRID, HPRD12270932 27229929 details
PTPN11NEDD9BioGRID, HPRD19275884 8879209 details
PTPN11EGFRBioGRID, HPRD, IntAct, MINT11223155 12270932 14560030 16273093 16729043 20473329 22973453 24935154 28065597 7588774 7673163 8959326 9756944 details
PTPN11PXNHPRD, IntAct, MINT10082579 10655584 14665621 23397142 24935154 8986614 details
PTPN11SRCBioGRID, HPRD, MINT14687660 20308328 8959326 details
PTPN11CRKLBioGRID, HPRD, IntAct23397142 9344843 9660791 details
PTPN11CSF3RBioGRID, HPRD9824671 details
PTPN11CATHPRD, MINT15556604 details
PTPN11ERBB4BioGRID, MINT16729043 22973453 28065597 details
PTPN11INSRBioGRID, HPRD, MINT7493946 8135823 8895367 9593725 details
PTPN11IRS1BioGRID, HPRD, MINT11781100 22974441 7513703 7935386 8505282 9535915 9756938 details
PTPN11PDGFRBBioGRID, HPRD, IntAct, MINT11266449 12614164 12681492 23397142 23922991 7530043 7688466 7691811 8041791 8119896 8183548 8538796 details
PTPN11IGF1RBioGRID, HPRD, MINT10082579 28065597 7642582 8895367 details
PTPN11ERBB3BioGRID, MINT22973453 28065597 9756944 details
PTPN11ROR2BioGRID, MINT28065597 details
PTPN11FLT1BioGRID, HPRD, IntAct23397142 25241761 9600074 details
PTPN11KITBioGRID, HPRD, IntAct12444928 24728074 7523381 9528781 details
PTPN11AATKBioGRID, MINT28065597 details
PTPN11PDGFRABioGRID, HPRD21996738 8943348 8959326 details
PTPN11HSPA9BioGRID19299420 details
PTPN11AKT1BioGRID19299420 details
PTPN11DDR1HPRD, MINT16337946 22057045 details
PTPN11TRIM32BioGRID, IntAct25416956 27229929 31515488 details
PTPN11CD244BioGRID, UniProt10358138 24642916 details
PTPN11KDRBioGRID, HPRD, MINT16339483 28065597 9405464 details
PTPN11STAT5ABioGRID, HPRD10617656 12060651 12237455 details
PTPN11PIK3CABioGRID26839216 9565634 9660791 details
PTPN11CD33BioGRID, HPRD, MINT10206955 17947393 details
PTPN11FCGR2BBioGRID, MINT10382761 11453982 9232445 details
PTPN11RPIABioGRID, IntAct, MINT21516116 25416956 details
PTPN11SYNCRIPBioGRID9847309 details
PTPN11STAT5BBioGRID, HPRD10617656 details
PTPN11EPORBioGRID, HPRD7534299 8639815 details
PTPN11POU2AF1BioGRID27229929 details
PTPN11SERF2BioGRID27229929 details
PTPN11HSPA5BioGRID19299420 details
PTPN11COASYBioGRID19763791 details
PTPN11SIT1BioGRID, HPRD, MINT10209036 11433379 11491537 details
PTPN11FRS3HPRD, MINT11432792 details
PTPN11SOCS3BioGRID, HPRD10777583 12403768 17138568 details
PTPN11PLEKHA4BioGRID27229929 31091453 details
PTPN11RANGRFBioGRID27229929 details
PTPN11SHC1BioGRID, HPRD10650943 11453982 details
PTPN11PTK2BBioGRID, HPRD10880513 details
PTPN11TXNIPBioGRID26527736 26919541 details
PTPN11NOX4BioGRID19299420 details
PTPN11LNX1BioGRID, IntAct25814554 details
PTPN11FGFR2BioGRID, MINT28065597 details
PTPN11FGFR4BioGRID, MINT28065597 details
PTPN11CEACAM1BioGRID, HPRD12108545 9867848 details
PTPN11GOLGA2BioGRID27229929 details
PTPN11PNCKBioGRID27229929 details
PTPN11SLC38A1BioGRID27229929 details
PTPN11BLZF1BioGRID27229929 details
PTPN11PIK3CGBioGRID, HPRD10386953 20723025 details
PTPN11KIR2DL1MINT9751747 details
PTPN11EPHA2BioGRID, HPRD, MINT, UniProt10655584 28065597 details
PTPN11CTDSP1BioGRID27229929 details
PTPN11SLNBioGRID27229929 details
PTPN11LRP1BioGRID23922991 details
PTPN11CALRBioGRID19299420 details
PTPN11MAPTBioGRID31201283 details
PTPN11ROS1BioGRID11266449 details
PTPN11INPP5DBioGRID, HPRD11157475 11453982 9110989 details
PTPN11GTF2A2BioGRID27229929 details
PTPN11CDC73BioGRID, IntAct21726809 26742426 details
PTPN11BEX2BioGRID27229929 details
PTPN11FAM71E1BioGRID27229929 details
PTPN11ORMDL3BioGRID27229929 details
PTPN11SRSF10BioGRID27229929 details
PTPN11TEKBioGRID, HPRD, MINT10521483 28065597 details
PTPN11FCRL3BioGRID12051764 details
PTPN11HSPD1BioGRID19299420 details
PTPN11FLT3BioGRID, MINT16684964 details
PTPN11GMNNBioGRID, IntAct32296183 details
PTPN11SPRY1IntAct24935154 details
PTPN11IL4RBioGRID, HPRD11714803 details
PTPN11TSC2BioGRID19299420 details
PTPN11NSUN5BioGRID27229929 details
PTPN11TRMT2BBioGRID27229929 details
PTPN11FBXW7BioGRID28287082 details
PTPN11DMRTC1BioGRID27229929 details
PTPN11ILKBioGRID19299420 details
PTPN11MAP3K5BioGRID19287004 details
PTPN11DDI1IntAct31515488 details
PTPN11SERPINF1BioGRID27229929 details
PTPN11HSP90B1BioGRID19299420 details
PTPN11MPIG6BBioGRID, HPRD, MINT11544253 details
PTPN11SOS1BioGRID, HPRD, IntAct16371368 20473329 9344843 9632781 details
PTPN11CBLBioGRID, HPRD11157475 17330819 18519587 details
PTPN11SHC4BioGRID28213521 details
PTPN11PRKCHHPRD11781100 details
PTPN11BTLABioGRID, HPRD, MINT12796776 14652006 details
PTPN11PDCD1BioGRID, IntAct, MINT15240681 28046066 28514442 details
PTPN11SELEBioGRID, HPRD, MINT11602579 details
PTPN11PILRABioGRID, HPRD10660620 10903717 details
PTPN11PLCG1HPRD, MINT15563458 9020117 details
PTPN11FYNBioGRID, HPRD10212213 11157475 details
PTPN11LY9BioGRID11689425 details
PTPN11PRLRBioGRID, HPRD10991949 14522994 details
PTPN11SOCS1BioGRID14522994 29991678 details
PTPN11FASNBioGRID23269672 details
PTPN11MVPHPRD15133037 15588985 details
PTPN11KLRC1HPRD9485206 details
PTPN11STAT3BioGRID, HPRD11594781 26775640 details
PTPN11LAIR1BioGRID, HPRD10903717 9285412 details
PTPN11WDR61BioGRID21726809 details
PTPN11CD274BioGRID11224527 details
PTPN11TIE1HPRD10949653 details
PTPN11PILRBHPRD10327049 11812650 details
PTPN11SIGLEC7BioGRID, HPRD10499918 15703304 details
PTPN11TRAF6BioGRID31942069 details
PTPN11HNRNPUHPRD8943344 details
PTPN11FLT4HPRD15102829 details
PTPN11GRIN2BHPRD10381539 details
PTPN11MPZL1BioGRID, HPRD, IntAct, MINT, UniProt10681522 11751924 28514442 9792637 details
PTPN11SGCGIntAct23414517 details
PTPN11MAPK3HPRD, IntAct23397142 8197172 details
PTPN11PAF1BioGRID21726809 27880917 details
PTPN11RTF1BioGRID21726809 details
PTPN11LIFRHPRD10800945 details
PTPN11CDH5BioGRID, HPRD10681592 details
PTPN11CXCR4BioGRID, HPRD11157475 details
PTPN11COP1BioGRID23269672 details
PTPN11MS4A2HPRD9379041 details
PTPN11KIR2DL3MINT8648092 details
PTPN11PTK2BioGRID, IntAct10082579 20473329 21726809 details
PTPN11IRS2BioGRID, HPRD8910607 details
PTPN11DDX58BioGRID28287082 details
PTPN11NTRK2HPRD10386953 details
PTPN11TREML1BioGRID, HPRD15128762 details
PTPN11PLCG2BioGRID12135708 details
PTPN11CTNNB1BioGRID10681592 details
PTPN11PTPN6BioGRID, HPRD27432908 8541543 details
PTPN11FGFR1BioGRID18022941 details
PTPN11ANXA2BioGRID9565634 details
PTPN11AXLHPRD15507525 details
PTPN11CTR9BioGRID21726809 27880917 details
PTPN11HDAC6BioGRID26775640 details
PTPN11BDKRB2HPRD12177051 details
PTPN11CTLA4HPRD8638161 details
PTPN11NTRK1BioGRID, HPRD25921289 9282923 details
PTPN11SIGLEC9BioGRID15703304 details
PTPN11IRS4HPRD12774026 details
PTPN11PVRBioGRID17717529 details
PTPN11CHUKHPRD11136824 details
PTPN11SLC4A1MINT12070037 details
PTPN11SIGLEC11BioGRID, HPRD11986327 details
PTPN11PRPF19BioGRID27213290 details
PTPN11BCRHPRD12115002 details
PTPN11BCAR1BioGRID9188452 details
PTPN11CBLBBioGRID17330819 details
PTPN11TAMALINBioGRID15173175 details
PTPN11PRKCAHPRD11781100 details
PTPN11ARHGAP1HPRD15169898 15588985 details
PTPN11MPLHPRD8541543 details
PTPN11GAB3BioGRID, HPRD11739737 details
PTPN11LRRK1BioGRID20697350 details
PTPN11ACTN4HPRD11382784 details
PTPN11IFNGR1HPRD10022928 details
PTPN11CRKBioGRID10464310 19380743 details
PTPN11DNM2BioGRID21996738 details
PTPN11RACK1BioGRID11964397 details
PTPN11PAG1HPRD10790433 details
PTPN11LEO1BioGRID21726809 details
PTPN11CLEC12ABioGRID15238421 details
PTPN11PRKCBHPRD11781100 details
PTPN11SPRY2HPRD15031289 details
PTPN11MAP3K4HPRD15601262 details
PTPN11CCKBRHPRD, MINT16963136 details
PTPN11ITGB3MINT12791772 details
PTPN11KIR2DL5AHPRD15187115 details
PTPN11RETHPRD12959980 details
PTPN11TNFRSF1AHPRD, MINT11786908 details
PTPN11DAB1HPRD15062102 details
PTPN11LCKHPRD10617656 details
PTPN11TYK2BioGRID9794795 details
PTPN11DOK1MINT15546884 details
PTPN11GAREM2BioGRID24003223 details
PTPN11TNIKIntAct31413325 details
PTPN11CD84BioGRID11689425 details
PTPN11E2F1BioGRID27720894 details
PTPN11IFNAR1HPRD9029147 details
PTPN11THEMISBioGRID, IntAct, MINT25535246 28514442 details
PTPN11LGALS3BioGRID, IntAct26186194 28514442 details
PTPN11FSD1BioGRID, IntAct26186194 28514442 details
PTPN11FCGR2ABioGRID, IntAct26186194 28514442 details
PTPN11OVCA2BioGRID, IntAct26186194 28514442 details
PTPN11AHCYL1BioGRID28675297 details
PTPN11SNRNP27BioGRID, IntAct28514442 details
PTPN11CYP1A1BioGRID, IntAct26186194 28514442 details
PTPN11EFHD2BioGRID22863883 details
PTPN11PSMA4BioGRID28675297 details
PTPN11VCAM1BioGRID, IntAct19738201 22623428 details
PTPN11TMEM220BioGRID, IntAct28514442 details
PTPN11NOSIPBioGRID, IntAct28514442 details
PTPN11SIGLEC5BioGRID, IntAct28514442 details
PTPN11LRRK2IntAct31046837 details
PTPN11PIH1D1BioGRID28515276 details
PTPN11PSMC6BioGRID28675297 details
PTPN11SLAMF6BioGRID, HPRD, IntAct11489943 details
PTPN11H2BC8BioGRID, MINT25281560 details
PTPN11GSK3BBioGRID22939629 details
PTPN11LUMBioGRID, IntAct28514442 details
PTPN11DCAF7BioGRID28675297 details
PTPN11GTF2E2BioGRID, IntAct28514442 details
PTPN11TCEAL1BioGRID, IntAct26186194 28514442 details
PTPN11PSMC3BioGRID28675297 details
PTPN11LGALS9BioGRID, IntAct26186194 28514442 31995728 details
PTPN11CCT4BioGRID28675297 details
PTPN11VCPBioGRID29599191 details
PTPN11NXT2BioGRID, IntAct28514442 details
PTPN11H2BC6MINT25281560 details
PTPN11PSMA6BioGRID28675297 details
PTPN11PSMB1BioGRID28675297 details
PTPN11KSR1IntAct27086506 details
PTPN11PPIFBioGRID22939629 details
PTPN11EFTUD2BioGRID28515276 details
PTPN11IQCB1BioGRID, IntAct21565611 details
PTPN11CD300AIntAct11489943 details
PTPN11GBF1BioGRID31519766 details
PTPN11CCT5BioGRID28675297 details
PTPN11ANXA1IntAct23754495 details
PTPN11GPX7BioGRID, IntAct28514442 details
PTPN11MAPK14BioGRID22863883 details
PTPN11FGBBioGRID, IntAct28514442 details
PTPN11DUSP13BioGRID27432908 details
PTPN11CCT8BioGRID28675297 details
PTPN11BRD4BioGRID32416067 details
PTPN11CCT7BioGRID28675297 details
PTPN11PRNPBioGRID, UniProt29791485 details
PTPN11MTPNBioGRID22863883 details
PTPN11CHRAC1BioGRID22863883 details
PTPN11PSMD12BioGRID28675297 details
PTPN11STAU1BioGRID30948266 details
PTPN11MAP2K1BioGRID26344197 details
PTPN11STAMBPBioGRID26344197 details
PTPN11CCT6BBioGRID28675297 details
PTPN11PIK3R2BioGRID, IntAct19380743 details
PTPN11H2BC10MINT25281560 details
PTPN11H2BC7MINT25281560 details
PTPN11OXCT1BioGRID22863883 details
PTPN11LRPPRCBioGRID28675297 details
PTPN11MED21BioGRID, IntAct28514442 details
PTPN11H2BC5MINT25281560 details
PTPN11H2BC4MINT25281560 details
PTPN11USP47BioGRID28675297 details
PTPN11PSMB4BioGRID28675297 details
PTPN11STIP1BioGRID28675297 details
PTPN11KCTD10BioGRID31280863 details
PTPN11TRIM25BioGRID29117863 details
PTPN11VIRMABioGRID29507755 details
PTPN11ELAVL1BioGRID19322201 details
PTPN11HNRNPH1BioGRID26760575 details