Entity Details

Primary name S4A8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ2Y0W8
EntryNameS4A8_HUMAN
FullNameElectroneutral sodium bicarbonate exchanger 1
TaxID9606
Evidenceevidence at protein level
Length1093
SequenceStatuscomplete
DateCreated2008-04-08
DateModified2021-06-02

Ontological Relatives

GenesSLC4A8

GO terms

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GOName
GO:0005452 inorganic anion exchanger activity
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0008510 sodium:bicarbonate symporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
GO:0015701 bicarbonate transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0022857 transmembrane transporter activity
GO:0030425 dendrite
GO:0032279 asymmetric synapse
GO:0032280 symmetric synapse
GO:0032809 neuronal cell body membrane
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043195 terminal bouton
GO:0043679 axon terminus
GO:0050801 ion homeostasis
GO:0050804 modulation of chemical synaptic transmission
GO:0051453 regulation of intracellular pH
GO:0055085 transmembrane transport
GO:0097386 glial cell projection
GO:0097457 hippocampal mossy fiber
GO:0098793 presynapse
GO:0098978 glutamatergic synapse
GO:0150104 transport across blood-brain barrier
GO:1902476 chloride transmembrane transport
GO:2000302 positive regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003020 Bicarbonate transporter, eukaryoticFamilyFamily
IPR003024 Sodium bicarbonate cotransporterFamilyFamily
IPR011531 Bicarbonate transporter, C-terminalDomainDomain
IPR013769 Band 3 cytoplasmic domainDomainDomain
IPR016152 Phosphotransferase/anion transporterFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01390 Sodium bicarbonateSwissprotsmall molecule

Interactions

4 interactions