Entity Details

Primary name SOS1
Entity type gene
Source Source Link

Details

PrimaryID6654
RefseqGeneNG_007530
SymbolSOS1
NameSOS Ras/Rac guanine nucleotide exchange factor 1
Chromosome2
Location2p22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsSOS1_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001782 B cell homeostasis
GO:0001942 hair follicle development
GO:0003209 cardiac atrium morphogenesis
GO:0003344 pericardium morphogenesis
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007296 vitellogenesis
GO:0007411 axon guidance
GO:0008286 insulin receptor signaling pathway
GO:0014069 postsynaptic density
GO:0017124 SH3 domain binding
GO:0019221 cytokine-mediated signaling pathway
GO:0033081 regulation of T cell differentiation in thymus
GO:0035264 multicellular organism growth
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0042129 regulation of T cell proliferation
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046982 protein heterodimerization activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0060021 roof of mouth development
GO:0061029 eyelid development in camera-type eye
GO:0061384 heart trabecula morphogenesis
GO:1904693 midbrain morphogenesis
GO:2000973 regulation of pro-B cell differentiation

Diseases

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Interactions

84 interactions

InteractorPartnerSourcesPublicationsLink
SOS1ABI1BioGRID, HPRD, MINT10499589 details
SOS1HCKHPRD, IntAct, MINT12029088 17141806 23397142 details
SOS1ITSN1BioGRID, HPRD, IntAct, MINT10716926 15824104 18539136 20936779 32203420 details
SOS1GRB2BioGRID, HPRD, IntAct, MINT, UniProt10025673 10207103 10319320 10477741 10570290 10716926 11726515 11960376 11964172 11997436 12577067 14679214 15192046 16520382 16893902 16906159 17474147 19323566 19380743 20473329 21706016 21988832 28166272 28514442 31980649 32062451 32203420 7510700 7514169 7516467 7527391 7559490 7629138 7629168 7642581 7664271 7773779 8112292 8188688 8479541 8493579 8626525 8695800 8810325 8816480 8943292 9009162 9344843 9447984 9478994 9569023 9716598 9797459 9872323 details
SOS1NCK1BioGRID, HPRD, IntAct10026169 10206341 17474147 32203420 7862111 8810325 details
SOS1HRASBioGRID, DIP, HPRD, IntAct, MINT11560935 12628188 15507210 17084389 18454158 19141281 20133692 26721396 9447984 9690470 details
SOS1SH3BP5BioGRID, IntAct17043677 31413325 details
SOS1PLCG1BioGRID, HPRD, IntAct, MINT10913276 10940929 17474147 9020117 details
SOS1CRKBioGRID, HPRD, IntAct17474147 19380743 25241761 31980649 32203420 8810325 8943292 details
SOS1SRCIntAct17474147 details
SOS1FYNBioGRID, HPRD, IntAct17474147 9856337 details
SOS1PIK3R1BioGRID, IntAct17474147 25241761 details
SOS1NEBMINT12482578 details
SOS1SH3PXD2AMINT19464300 details
SOS1HDLBPBioGRID, IntAct20936779 details
SOS1ITSN2BioGRID, IntAct20936779 22558309 details
SOS1SPTAN1BioGRID, IntAct20936779 details
SOS1NOSTRINMINT22751148 details
SOS1UBASH3ABioGRID, IntAct32296183 details
SOS1EGFRBioGRID, DIP, HPRD, IntAct10675333 18271526 19289468 19531499 20473329 23956138 24797263 25754235 26005835 31959764 7510700 8621459 9447973 details
SOS1COPS3BioGRID, MINT30631038 details
SOS1BIN1BioGRID, HPRD, IntAct32203420 9182529 details
SOS1ANXA2BioGRID7510700 details
SOS1TNIKBioGRID17043677 details
SOS1LCKBioGRID16274251 details
SOS1MAPK3BioGRID8621459 details
SOS1SIRPABioGRID19299420 details
SOS1ABI3HPRD11956071 details
SOS1PACSIN3HPRD, IntAct14679214 details
SOS1SNX9HPRD, IntAct14679214 details
SOS1CD2APBioGRID, HPRD, IntAct14679214 32203420 details
SOS1SNX18HPRD, IntAct14679214 details
SOS1SHC1BioGRID, HPRD, IntAct, MINT10025673 10570290 10675333 10783152 16371368 19380743 7520523 7559490 8235613 8621459 8626525 8631299 8950973 9344843 9544989 details
SOS1EPS8BioGRID, HPRD, MINT10499589 14565974 16520382 27629044 details
SOS1FGFR1BioGRID, HPRD, IntAct25241761 9480847 details
SOS1CRKLBioGRID, HPRD, IntAct23397142 26496610 32203420 9162067 details
SOS1GAB1HPRD, IntAct11707404 23397142 details
SOS1PACSIN1HPRD, IntAct11352907 31413325 details
SOS1PTPN11BioGRID, HPRD, IntAct16371368 20473329 9344843 9632781 details
SOS1EPS8L1BioGRID, HPRD14565974 details
SOS1EPS8L2BioGRID, HPRD14565974 details
SOS1SH3KBP1BioGRID, HPRD11071869 details
SOS1BCRBioGRID7529874 8112292 details
SOS1ABL1BioGRID8112292 details
SOS1NF2BioGRID10675333 details
SOS1FRS2BioGRID, HPRD10783152 11997436 16893902 9182757 9797459 details
SOS1MUC1BioGRID11278868 7664271 details
SOS1PTPN6BioGRID, HPRD8632004 details
SOS1GRAPBioGRID, HPRD8647802 details
SOS1METBioGRID9660480 details
SOS1RIT2BioGRID, HPRD12099688 details
SOS1NCK2BioGRID, HPRD10026169 details
SOS1SRRM1BioGRID16159877 details
SOS1CSF1RBioGRID, HPRD10025673 7520523 details
SOS1CBLBioGRID10025673 details
SOS1SORBS1BioGRID17548467 details
SOS1TNFRSF1ABioGRID19289468 details
SOS1LRRK1BioGRID20697350 details
SOS1LATBioGRID16906159 details
SOS1RAC1BioGRID27629044 details
SOS1COPS7ABioGRID30631038 details
SOS1RRASHPRD11560935 details
SOS1ZAP70HPRD7629168 details
SOS1ERBB3HPRD11173924 details
SOS1ATP6V1E1HPRD11560919 details
SOS1MAPK1HPRD8816480 details
SOS1SOS1HPRD14656442 details
SOS1CAV1HPRD15976327 details
SOS1CD19HPRD10706702 details
SOS1ESR1HPRD15173068 details
SOS1PIK3R2HPRD9651378 details
SOS1RANBP9HPRD12147692 details
SOS1LAT2HPRD12486104 details
SOS1ERBB2HPRD11173924 details
SOS1RETIntAct19914172 details
SOS1H1-5BioGRID, IntAct30021884 details
SOS1APPL2UniProt24879834 details
SOS1TXNDC5BioGRID, IntAct32203420 details
SOS1PTK2IntAct20473329 details
SOS1NTRK1BioGRID25921289 details
SOS1PSMD14BioGRID30745168 details
SOS1BRD8BioGRID31753913 details
SOS1EPS15L1BioGRID32203420 details
SOS1NME2BioGRID32203420 details