Entity Details

Primary name ADAM17
Entity type gene
Source Source Link

Details

PrimaryID6868
RefseqGeneNG_029873
SymbolADAM17
NameADAM metallopeptidase domain 17
Chromosome2
Location2p25.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-11
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsADA17_HUMAN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002446 neutrophil mediated immunity
GO:0002467 germinal center formation
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005112 Notch binding
GO:0005138 interleukin-6 receptor binding
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010820 positive regulation of T cell chemotaxis
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016485 protein processing
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
GO:0030183 B cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031293 membrane protein intracellular domain proteolysis
GO:0032496 response to lipopolysaccharide
GO:0032722 positive regulation of chemokine production
GO:0033025 regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033627 cell adhesion mediated by integrin
GO:0035313 wound healing, spreading of epidermal cells
GO:0035624 receptor transactivation
GO:0042493 response to drug
GO:0042987 amyloid precursor protein catabolic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045121 membrane raft
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0046872 metal ion binding
GO:0048536 spleen development
GO:0048870 cell motility
GO:0050830 defense response to Gram-positive bacterium
GO:0051272 positive regulation of cellular component movement
GO:0071403 cellular response to high density lipoprotein particle stimulus
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway
GO:1905564 positive regulation of vascular endothelial cell proliferation

Diseases

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Interactions

56 interactions

InteractorPartnerSourcesPublicationsLink
ADAM17MAD2L1BioGRID, HPRD, UniProt10527948 11741929 details
ADAM17PTPN3HPRD, MINT12207026 details
ADAM17DLG1BioGRID, HPRD, MINT12668732 18930083 details
ADAM17PDIA3BioGRID, MINT17170699 details
ADAM17APPIntAct9774383 details
ADAM17JAG1IntAct23375636 details
ADAM17ITGB1IntAct, UniProt22413019 30455686 details
ADAM17PDPK1DIP16641105 details
ADAM17MAPK1BioGRID12058067 details
ADAM17TIMP3BioGRID, HPRD12044879 details
ADAM17TNFRSF1ABioGRID17010968 details
ADAM17TNFRSF1BBioGRID17010968 details
ADAM17FHL2HPRD16619241 details
ADAM17TGFABioGRID, HPRD, IntAct11823465 18930083 25241761 details
ADAM17SRCDIP16641105 details
ADAM17ITGAVUniProt30455686 details
ADAM17SNX18UniProt25036101 details
ADAM17SNX9UniProt25036101 details
ADAM17SNX33UniProt25036101 details
ADAM17PACSIN1UniProt25036101 details
ADAM17PACSIN2UniProt25036101 details
ADAM17PACSIN3UniProt25036101 details
ADAM17EEDBioGRID23317503 details
ADAM17PXNBioGRID23317503 details
ADAM17NOTCH1HPRD10882063 9620803 details
ADAM17TNFHPRD10799478 12135369 details
ADAM17ERBB4HPRD15534001 details
ADAM17MAD2L2HPRD10527948 details
ADAM17SH3D19HPRD15280379 details
ADAM17TNFSF11HPRD10224132 details
ADAM17INSL5BioGRID, IntAct28514442 details
ADAM17ST8SIA4BioGRID, IntAct28514442 details
ADAM17LMAN2LBioGRID, IntAct28514442 details
ADAM17LRRC3BioGRID, IntAct28514442 details
ADAM17SDK2BioGRID, IntAct28514442 details
ADAM17CD9UniProt26686862 30455686 details
ADAM17TSPAN5UniProt26686862 details
ADAM17TSPAN15UniProt26686862 details
ADAM17TSPAN12UniProt19587294 details
ADAM17CD81IntAct32900848 details
ADAM17FBXO6BioGRID22268729 32409323 details
ADAM17PTCH1BioGRID26186194 details
ADAM17CDH1BioGRID25468996 details
ADAM17CFTRBioGRID26618866 details
ADAM17RNF4BioGRID29180619 details
ADAM17AGRNBioGRID29872149 details
ADAM17RHBDF2BioGRID31177093 details
ADAM17OTULINLBioGRID31056421 details
ADAM17BRPF3BioGRID31753913 details
ADAM17BCAP31BioGRID34079125 details
ADAM17DERL1BioGRID34079125 details
ADAM17HSD17B11BioGRID34079125 details
ADAM17RPN2BioGRID34079125 details
ADAM17SEC61BBioGRID34079125 details
ADAM17SEC62BioGRID34079125 details
ADAM17HNRNPH1BioGRID26760575 details