Entity Details

Primary name GDF15
Entity type gene
Source Source Link

Details

PrimaryID9518
RefseqGene
SymbolGDF15
Namegrowth differentiation factor 15
Chromosome19
Location19p13.11
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-04-20
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsGDF15_HUMAN

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002023 reduction of food intake in response to dietary excess
GO:0005125 cytokine activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030509 BMP signaling pathway
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
GO:0040015 negative regulation of multicellular organism growth
GO:0042803 protein homodimerization activity
GO:0043410 positive regulation of MAPK cascade
GO:0051897 positive regulation of protein kinase B signaling
GO:0060395 SMAD protein signal transduction
GO:0060400 negative regulation of growth hormone receptor signaling pathway
GO:0070062 extracellular exosome
GO:0070700 BMP receptor binding
GO:1901741 positive regulation of myoblast fusion

Diseases

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Interactions

20 interactions

InteractorPartnerSourcesPublicationsLink
GDF15MAPK14BioGRID, IntAct18624398 details
GDF15MDFIBioGRID, IntAct19060904 32296183 details
GDF15KRTAP12-2BioGRID, IntAct32296183 details
GDF15TACC3BioGRID, IntAct32296183 details
GDF15HOXA1BioGRID, IntAct32296183 details
GDF15CBX3BioGRID, IntAct32296183 details
GDF15NLGN3BioGRID, IntAct25464930 details
GDF15GDF15BioGRID, HPRD10811612 11141057 9326641 details
GDF15STAT5ABioGRID, IntAct26496610 details
GDF15NUP58BioGRID, IntAct26496610 details
GDF15SAE1BioGRID, IntAct26496610 details
GDF15SETD4BioGRID, IntAct26496610 details
GDF15MRPL50BioGRID, IntAct26496610 details
GDF15RMND5AIntAct28514442 details
GDF15ENGBioGRID, UniProt31540324 details
GDF15PRKCBBioGRID, IntAct31980649 details
GDF15PRKD1BioGRID, IntAct31980649 details
GDF15TAGLNMINT32774160 details
GDF15SQSTM1BioGRID30581152 details
GDF15ARBioGRID32814769 details