Entity Details

Primary name MDC1
Entity type gene
Source Source Link

Details

PrimaryID9656
RefseqGene
SymbolMDC1
Namemediator of DNA damage checkpoint 1
Chromosome6
Location6p21.33
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-11-30
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsMDC1_HUMAN

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005925 focal adhesion
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0008022 protein C-terminus binding
GO:0016604 nuclear body
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0070975 FHA domain binding

Diseases

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Interactions

374 interactions

InteractorPartnerSourcesPublicationsLink
MDC1NBNBioGRID, DIP, HPRD, IntAct, MINT, UniProt12607003 12607005 14519663 15201865 15377652 18001824 18583988 18678890 19804756 20224574 20460517 23115235 25064736 29656893 30179224 details
MDC1RAD50BioGRID, MINT, UniProt12607003 12607005 14519663 18583988 29656893 30179224 details
MDC1ATMBioGRID, HPRD, UniProt12607005 14519663 18006705 26734725 28943310 29656893 details
MDC1TP53BP1BioGRID, HPRD, UniProt12607005 17925396 18986980 29656893 30179224 details
MDC1MRE11BioGRID, MINT, UniProt12607003 12607005 14519663 18583988 29656893 30179224 details
MDC1H2AXBioGRID, DIP, HPRD, IntAct, MINT, UniProt12475977 12607005 14519663 15201865 16377563 18001824 18001825 18583988 19234442 20159462 21293379 21622030 21676867 26734725 28242625 29499138 30598506 32518374 details
MDC1RNF8BioGRID, DIP, HPRD, IntAct18001824 18001825 18006705 24240613 25512560 26734725 28943310 details
MDC1CSNK2A1BioGRID, MINT18583988 details
MDC1LOXmatrixdb25118846 details
MDC1RAD51BioGRID, DIP16186822 28973861 details
MDC1NSD2BioGRID, DIP21293379 31248990 details
MDC1UIMC1BioGRID, DIP, UniProt21622030 21857162 22990118 24240613 29656893 details
MDC1TOPBP1BioGRID, UniProt21482717 24239288 29656893 details
MDC1BDKRB1BioGRID, MINT28298427 details
MDC1CENPCBioGRID14578343 details
MDC1GATA4BioGRID14578343 details
MDC1HDAC10BioGRID14578343 details
MDC1HDAC8BioGRID14578343 details
MDC1MDM2BioGRID14578343 18471438 details
MDC1POLR2ABioGRID14578343 22990118 details
MDC1WRNBioGRID14578343 details
MDC1CHEK2BioGRID, HPRD12475977 12551934 12607004 details
MDC1ANAPC1BioGRID17827148 19826003 22990118 details
MDC1CDC27BioGRID17827148 19826003 22942284 details
MDC1CASP3BioGRID21148072 details
MDC1PRKDCBioGRID15377652 details
MDC1XRCC5BioGRID15377652 details
MDC1PIAS1BioGRID22661230 details
MDC1PIAS4BioGRID22661230 details
MDC1CDC20BioGRID19826003 22990118 details
MDC1CREBBPBioGRID, HPRD16051665 19826003 details
MDC1HINFPBioGRID17577209 details
MDC1AMFRBioGRID22990118 details
MDC1AUP1BioGRID22990118 details
MDC1CLUBioGRID22990118 details
MDC1PRIM1BioGRID22990118 details
MDC1RPL29BioGRID22990118 details
MDC1VAMP5BioGRID22990118 details
MDC1COPS5BioGRID22990118 details
MDC1ZNF251BioGRID22990118 details
MDC1DTX2BioGRID22990118 details
MDC1NCLBioGRID23145133 details
MDC1SUMO2BioGRID19394292 32786267 details
MDC1SRPK2BioGRID26167880 details
MDC1USP13BioGRID28569838 details
MDC1USP7BioGRID30179224 details
MDC1TNKSBioGRID26845027 details
MDC1TNKS2BioGRID26845027 details
MDC1USP15BioGRID30874560 details
MDC1PTENBioGRID31217297 details
MDC1BRCA1BioGRID, HPRD, IntAct, UniProt12607005 12611903 15569676 17525332 19766185 21622030 29656893 details
MDC1MDC1BioGRID, DIP, HPRD, UniProt12607005 14519663 21293379 29656893 details
MDC1JMJD1CDIP24240613 details
MDC1BARD1BioGRID, HPRD, UniProt12611903 29656893 details
MDC1TP53BioGRID, HPRD14519663 details
MDC1USP28BioGRID, HPRD16901786 details
MDC1BANF1BioGRID19759913 details
MDC1MCPH1BioGRID16872911 details
MDC1ANAPC5BioGRID17827148 22990118 details
MDC1CDC16BioGRID17827148 19826003 22990118 details
MDC1BIRC5BioGRID20394854 details
MDC1HERC2BioGRID20023648 details
MDC1EP300BioGRID, HPRD16051665 details
MDC1RNF4BioGRID22661230 details
MDC1PSMD4BioGRID22661229 details
MDC1ANAPC7BioGRID19826003 22990118 details
MDC1RAG1BioGRID22942284 details
MDC1WRAP53BioGRID25512560 26734725 27715493 details
MDC1ATXN3BioGRID28275011 details
MDC1ASF1ABioGRID28943310 details
MDC1CTCFBioGRID28973861 details
MDC1TRIM29BioGRID26095369 details
MDC1SENP2BioGRID30796017 details
MDC1SYCP3BioGRID31043422 details
MDC1SMC1ABioGRID, HPRD, UniProt12607005 details
MDC1FANCD2BioGRID, UniProt12607005 29656893 31180492 details
MDC1TERF2IPBioGRID, IntAct15383534 34079125 details
MDC1AIM2BioGRID, IntAct25665578 details
MDC1PYHIN1BioGRID, IntAct25665578 details
MDC1JUNMINT25609649 details
MDC1GTF2E2BioGRID, IntAct28514442 details
MDC1SH3KBP1BioGRID, IntAct28514442 details
MDC1USP47BioGRID, IntAct28514442 details
MDC1ESAMBioGRID, IntAct28514442 details
MDC1CDK8BioGRID, IntAct29568061 details
MDC1H3C1BioGRID, IntAct29568061 34079125 details
MDC1H3C4IntAct29568061 details
MDC1H3C3IntAct29568061 details
MDC1H3C6IntAct29568061 details
MDC1H3C11IntAct29568061 details
MDC1H3C8IntAct29568061 details
MDC1H3C12IntAct29568061 details
MDC1H3C10IntAct29568061 details
MDC1H3C2IntAct29568061 details
MDC1H3C7IntAct29568061 details
MDC1DLSTBioGRID, IntAct29128334 details
MDC1MIS12BioGRID, UniProt29656893 details
MDC1ETV6BioGRID, UniProt29656893 details
MDC1DSN1BioGRID, UniProt29656893 details
MDC1DGCR8BioGRID, UniProt29656893 details
MDC1KNL1BioGRID, UniProt29656893 details
MDC1ANK2UniProt29656893 details
MDC1ARID1BBioGRID, UniProt29656893 details
MDC1ARID1ABioGRID, UniProt29656893 details
MDC1RPA1BioGRID, UniProt24332808 29656893 details
MDC1CDH13BioGRID, UniProt29656893 details
MDC1ZNF148BioGRID, UniProt29656893 details
MDC1ZNF106BioGRID, UniProt29656893 details
MDC1ZBTB2BioGRID, UniProt29656893 details
MDC1TPX2BioGRID, UniProt29656893 details
MDC1WDR26BioGRID, UniProt29656893 details
MDC1INTS14BioGRID, UniProt29656893 details
MDC1TOX4UniProt29656893 details
MDC1TCF20BioGRID, UniProt29656893 details
MDC1SMARCD3BioGRID, UniProt29656893 details
MDC1KIF6UniProt29656893 details
MDC1SUDS3BioGRID, UniProt29656893 details
MDC1SPECC1LBioGRID, UniProt29656893 details
MDC1SLX4IPBioGRID, UniProt29656893 details
MDC1SLC4A1APBioGRID, UniProt29656893 details
MDC1SIN3BBioGRID, UniProt29656893 details
MDC1SIN3ABioGRID, UniProt29656893 details
MDC1CAVIN2BioGRID, UniProt29656893 details
MDC1RPRD2BioGRID, UniProt29656893 details
MDC1RNMTBioGRID, UniProt29656893 details
MDC1RBM10BioGRID, UniProt29656893 details
MDC1QRICH1BioGRID, UniProt29656893 details
MDC1PHF3BioGRID, UniProt29656893 details
MDC1PHF12BioGRID, UniProt29656893 details
MDC1PHC1BioGRID, UniProt29656893 details
MDC1PARNBioGRID, UniProt29656893 details
MDC1OSBPL10UniProt29656893 details
MDC1OIP5BioGRID, UniProt29656893 details
MDC1OGTBioGRID, UniProt29656893 details
MDC1NUDT21BioGRID, UniProt29656893 details
MDC1NSD1BioGRID, UniProt29656893 details
MDC1NFICBioGRID, UniProt29656893 details
MDC1NCOR2UniProt29656893 details
MDC1MSL1BioGRID, UniProt29656893 details
MDC1MRGBPBioGRID, UniProt29656893 details
MDC1MGABioGRID, UniProt29656893 details
MDC1SMARCE1BioGRID, UniProt29656893 details
MDC1MED12BioGRID, UniProt29656893 details
MDC1SMARCB1BioGRID, UniProt29656893 details
MDC1KDM1BBioGRID, UniProt29656893 details
MDC1KANSL2BioGRID, UniProt29656893 details
MDC1IMPDH2BioGRID, UniProt29656893 details
MDC1ICE1BioGRID, UniProt29656893 details
MDC1HNRNPABBioGRID, UniProt29656893 details
MDC1GTF3C5BioGRID, UniProt29656893 details
MDC1GTF3C1BioGRID, UniProt29656893 details
MDC1FUBP1BioGRID, UniProt29656893 details
MDC1FLYWCH1BioGRID, UniProt29656893 details
MDC1FHL1BioGRID, UniProt29656893 details
MDC1TRIM33BioGRID, UniProt29656893 details
MDC1SMARCC2BioGRID, UniProt26344197 29656893 details
MDC1SMARCC1BioGRID, UniProt26344197 29656893 details
MDC1SMARCD1BioGRID, UniProt26344197 29656893 details
MDC1EXOSC8BioGRID, UniProt22990118 29656893 details
MDC1EXOC3L2BioGRID, UniProt29656893 details
MDC1MIDEASBioGRID, UniProt29656893 details
MDC1ILF2BioGRID, UniProt29656893 details
MDC1DPY30BioGRID, UniProt29656893 details
MDC1DNTTIP1BioGRID, UniProt29656893 details
MDC1PMLBioGRID, UniProt29656893 details
MDC1DDX39BBioGRID, UniProt29656893 details
MDC1CTBP2UniProt29656893 details
MDC1CSTF2UniProt29656893 details
MDC1CRYABBioGRID, UniProt29656893 details
MDC1CPSF6BioGRID, UniProt22990118 29656893 details
MDC1COL6A2BioGRID, UniProt29656893 details
MDC1TRIM28BioGRID, UniProt29656893 details
MDC1CENPUBioGRID, UniProt29656893 details
MDC1CENPPBioGRID, UniProt29656893 details
MDC1SS18UniProt29656893 details
MDC1CCDC9BioGRID, UniProt29656893 details
MDC1CBX2BioGRID, UniProt29656893 details
MDC1KHSRPBioGRID, UniProt29656893 details
MDC1BOD1UniProt29656893 details
MDC1BEND3BioGRID, UniProt29656893 details
MDC1EWSR1BioGRID, UniProt29656893 details
MDC1ASH2LBioGRID, UniProt29656893 details
MDC1ANLNBioGRID, UniProt29656893 details
MDC1POLD1BioGRID, UniProt29656893 details
MDC1ORC3BioGRID, UniProt29656893 details
MDC1PWWP3ABioGRID, UniProt29656893 details
MDC1ZBTB1BioGRID, UniProt29656893 details
MDC1LIG3BioGRID, UniProt29656893 details
MDC1SETD2BioGRID, UniProt29656893 details
MDC1SCAIBioGRID, UniProt29656893 details
MDC1SMCHD1BioGRID, UniProt29656893 details
MDC1SFPQBioGRID, UniProt29656893 details
MDC1NSMCE3BioGRID, UniProt29656893 details
MDC1EMSYBioGRID, UniProt29656893 details
MDC1BRCA2BioGRID, UniProt29656893 details
MDC1YY1UniProt29656893 details
MDC1SMC5BioGRID, UniProt29656893 details
MDC1SMC6BioGRID, UniProt29656893 details
MDC1TERF2BioGRID, UniProt29656893 details
MDC1TLK1UniProt29656893 details
MDC1NSMCE1BioGRID, UniProt29656893 details
MDC1TOP1UniProt29656893 details
MDC1ACDBioGRID, UniProt29656893 details
MDC1TERF1BioGRID, UniProt29656893 details
MDC1RNF169BioGRID, UniProt29656893 details
MDC1ERCC1BioGRID, UniProt29656893 details
MDC1RECQLBioGRID, UniProt29656893 details
MDC1ZNF207BioGRID, UniProt29656893 details
MDC1ERCC4BioGRID, UniProt29656893 details
MDC1SLX4BioGRID, UniProt29656893 details
MDC1TINF2BioGRID, UniProt29656893 details
MDC1POT1BioGRID, UniProt29656893 details
MDC1BABAM2BioGRID, UniProt22990118 29656893 details
MDC1BABAM1BioGRID, UniProt22990118 29656893 details
MDC1RIF1BioGRID, UniProt29656893 details
MDC1BRCC3BioGRID, UniProt22990118 29656893 details
MDC1FUSBioGRID, UniProt29656893 details
MDC1ATAD5BioGRID, UniProt29656893 details
MDC1NEK4BioGRID, MINT25798074 details
MDC1TCF7L2BioGRID, IntAct30833792 details
MDC1ESR1BioGRID, IntAct31527615 details
MDC1SIRT7BioGRID22586326 details
MDC1TFAP4BioGRID19505873 details
MDC1ATP2A2BioGRID22990118 details
MDC1CAPZA1BioGRID22990118 details
MDC1CAPZBBioGRID22990118 details
MDC1CDC5LBioGRID22990118 details
MDC1CSRP2BioGRID22990118 details
MDC1EMDBioGRID22990118 details
MDC1ENO1BioGRID22990118 details
MDC1EPS8BioGRID22990118 details
MDC1FLNABioGRID22990118 details
MDC1FLNBBioGRID22990118 details
MDC1HNRNPCBioGRID22990118 details
MDC1KPNB1BioGRID22990118 details
MDC1MKI67BioGRID22990118 details
MDC1MPGBioGRID22990118 details
MDC1MYO1DBioGRID22990118 details
MDC1NDUFA10BioGRID22990118 details
MDC1NUMA1BioGRID22990118 details
MDC1PDHBBioGRID22990118 details
MDC1PLRG1BioGRID22990118 details
MDC1POLR2BBioGRID22990118 details
MDC1POLR2CBioGRID22990118 details
MDC1POLR2EBioGRID22990118 details
MDC1PPP1CABioGRID22990118 details
MDC1PPP2CABioGRID22990118 details
MDC1ABCD3BioGRID22990118 details
MDC1PYCR1BioGRID22990118 details
MDC1RFC2BioGRID22990118 details
MDC1RFC4BioGRID22990118 details
MDC1RFC5BioGRID22990118 details
MDC1ATXN2BioGRID22990118 details
MDC1SRSF1BioGRID22990118 details
MDC1SMN1BioGRID22990118 details
MDC1SNRPBBioGRID22990118 details
MDC1SSR1BioGRID22990118 details
MDC1STAU1BioGRID22990118 details
MDC1SUPT6HBioGRID22990118 details
MDC1TPM1BioGRID22990118 details
MDC1TPM3BioGRID22990118 details
MDC1VDAC1BioGRID22990118 details
MDC1VDAC2BioGRID22990118 details
MDC1YWHAZBioGRID22990118 details
MDC1SLC25A11BioGRID22990118 details
MDC1TAGLN2BioGRID22990118 details
MDC1PRKRABioGRID22990118 details
MDC1SRSF9BioGRID22990118 details
MDC1CDC23BioGRID22990118 details
MDC1TRIP13BioGRID22990118 details
MDC1RECQL5BioGRID22990118 details
MDC1SNRNP40BioGRID22990118 details
MDC1RBM39BioGRID22990118 details
MDC1THRAP3BioGRID22990118 details
MDC1SF3A1BioGRID22990118 details
MDC1ANAPC10BioGRID22990118 details
MDC1RACK1BioGRID22990118 details
MDC1MYL12ABioGRID22990118 details
MDC1CPSF4BioGRID22990118 details
MDC1IMMTBioGRID22990118 details
MDC1COPEBioGRID22990118 details
MDC1PHB2BioGRID22990118 details
MDC1CBX3BioGRID22990118 34079125 details
MDC1POGZBioGRID22990118 details
MDC1U2SURPBioGRID22990118 details
MDC1EXOSC2BioGRID22990118 details
MDC1RAI14BioGRID22990118 details
MDC1SERBP1BioGRID22990118 details
MDC1PHGDHBioGRID22990118 details
MDC1ANAPC2BioGRID22990118 details
MDC1PYCR2BioGRID22990118 details
MDC1SEC61A1BioGRID22990118 details
MDC1ANAPC4BioGRID22990118 details
MDC1PDZD11BioGRID22990118 details
MDC1FZR1BioGRID22990118 details
MDC1CPSF3BioGRID22990118 details
MDC1PELOBioGRID22990118 details
MDC1CPSF2BioGRID22990118 details
MDC1PAF1BioGRID22990118 details
MDC1CHCHD3BioGRID22990118 details
MDC1RADXBioGRID22990118 details
MDC1RMDN3BioGRID22990118 details
MDC1WDR33BioGRID22990118 details
MDC1CDKN2AIPBioGRID22990118 details
MDC1LYARBioGRID22990118 details
MDC1DEPDC1BBioGRID22990118 details
MDC1WDR18BioGRID22990118 details
MDC1MICAL3BioGRID22990118 details
MDC1METTL17BioGRID22990118 details
MDC1COA7BioGRID22990118 details
MDC1C2orf49BioGRID22990118 details
MDC1HMBOX1BioGRID22990118 details
MDC1ZNF768BioGRID22990118 details
MDC1SLC25A22BioGRID22990118 details
MDC1MYH14BioGRID22990118 details
MDC1LPCAT1BioGRID22990118 details
MDC1LAS1LBioGRID22990118 details
MDC1ABRAXAS1BioGRID22990118 29656893 details
MDC1RBM17BioGRID22990118 30179224 details
MDC1OSBPL8BioGRID22990118 details
MDC1ANAPC16BioGRID22990118 details
MDC1LSM12BioGRID22990118 details
MDC1PGAM5BioGRID22990118 details
MDC1HNRNPUL2BioGRID22990118 details
MDC1CHAMP1BioGRID22990118 details
MDC1PAXIP1BioGRID22990118 details
MDC1LMNABioGRID22412018 30179224 30419336 details
MDC1RPA3BioGRID24332808 details
MDC1RPA2BioGRID24332808 details
MDC1CUL7BioGRID24711643 details
MDC1OBSL1BioGRID24711643 details
MDC1EEDBioGRID24457600 details
MDC1HNRNPUBioGRID26344197 details
MDC1SMARCA4BioGRID26344197 details
MDC1SMARCD2BioGRID26344197 details
MDC1SSBP3BioGRID26344197 details
MDC1PCGF1BioGRID26687479 details
MDC1DPPA4BioGRID26687479 details
MDC1EFTUD2BioGRID28515276 details
MDC1NKX2-1BioGRID28192407 details
MDC1CHD4BioGRID28977666 details
MDC1ESR2BioGRID29509190 details
MDC1UBR5BioGRID30179224 details
MDC1TRIP12BioGRID30179224 details
MDC1PRC1BioGRID30179224 31586073 details
MDC1DCPSBioGRID29478914 details
MDC1TNRC6ABioGRID28813667 details
MDC1MYCBioGRID29467282 details
MDC1H4C1BioGRID27248496 30804502 details
MDC1H2BC3BioGRID27248496 details
MDC1AFG3L2BioGRID29656893 details
MDC1BOD1L1BioGRID29656893 details
MDC1ACTC1BioGRID30890647 details
MDC1RBX1BioGRID30349055 details
MDC1UBQLN2BioGRID30442662 details
MDC1XRCC6BioGRID30585729 details
MDC1VRK1BioGRID28927264 details
MDC1ITFG1BioGRID25437307 details
MDC1BIRC3BioGRID30948266 details
MDC1PLEKHA4BioGRID31091453 details
MDC1CITBioGRID31586073 details
MDC1AURKBBioGRID31586073 details
MDC1CHMP4CBioGRID31586073 details
MDC1ECT2BioGRID31586073 details
MDC1KIF14BioGRID31586073 details
MDC1KIF20ABioGRID31586073 details
MDC1IFI16BioGRID25665578 details
MDC1USP14BioGRID31740976 details
MDC1NUPR1BioGRID32780723 details
MDC1BRD4BioGRID32416067 details
MDC1MKRN1BioGRID32460013 details
MDC1H2BC8BioGRID34079125 details
MDC1ELAVL1BioGRID19322201 details
MDC1DDX58BioGRID32513696 details