Entity Details

Primary name RAPGEF2
Entity type gene
Source Source Link

Details

PrimaryID9693
RefseqGeneNG_063926
SymbolRAPGEF2
NameRap guanine nucleotide exchange factor 2
Chromosome4
Location4q32.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-03-24
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsRPGF2_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001568 blood vessel development
GO:0001764 neuron migration
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005923 bicellular tight junction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008285 negative regulation of cell population proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019933 cAMP-mediated signaling
GO:0019992 diacylglycerol binding
GO:0021591 ventricular system development
GO:0021884 forebrain neuron development
GO:0030033 microvillus assembly
GO:0030139 endocytic vesicle
GO:0030165 PDZ domain binding
GO:0030552 cAMP binding
GO:0031175 neuron projection development
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0031697 beta-1 adrenergic receptor binding
GO:0032092 positive regulation of protein binding
GO:0032486 Rap protein signal transduction
GO:0032991 protein-containing complex
GO:0035556 intracellular signal transduction
GO:0038180 nerve growth factor signaling pathway
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043547 positive regulation of GTPase activity
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045202 synapse
GO:0045860 positive regulation of protein kinase activity
GO:0048022 negative regulation of melanin biosynthetic process
GO:0048167 regulation of synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0050699 WW domain binding
GO:0050774 negative regulation of dendrite morphogenesis
GO:0061028 establishment of endothelial barrier
GO:0070300 phosphatidic acid binding
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0072659 protein localization to plasma membrane
GO:0090557 establishment of endothelial intestinal barrier
GO:1901888 regulation of cell junction assembly
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000481 positive regulation of cAMP-dependent protein kinase activity
GO:2000670 positive regulation of dendritic cell apoptotic process
GO:2001214 positive regulation of vasculogenesis
GO:2001224 positive regulation of neuron migration

Diseases

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Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
RAPGEF2MAGI2HPRD, MINT10548487 details
RAPGEF2ATP8BioGRID, IntAct20936779 details
RAPGEF2HSPA1ABioGRID, IntAct20936779 details
RAPGEF2KIF5ABioGRID, IntAct20936779 details
RAPGEF2KIF5BBioGRID, IntAct20936779 details
RAPGEF2MOB4BioGRID, IntAct20936779 details
RAPGEF2NEDD4BioGRID, MINT11598133 21765395 24340059 details
RAPGEF2NEDD4LMINT21765395 details
RAPGEF2RAP1ABioGRID, HPRD, UniProt10608844 10608883 10934204 details
RAPGEF2HRASUniProt10608844 details
RAPGEF2MAGI1BioGRID, IntAct, UniProt11168587 25332235 28514442 details
RAPGEF2RALGDSBioGRID7809086 details
RAPGEF2RAP2BBioGRID, HPRD10608883 10934204 details
RAPGEF2SPP1BioGRID22779921 details
RAPGEF2IL16BioGRID32296183 details
RAPGEF2PHB2IntAct17353931 details
RAPGEF2YWHAZMINT15161933 details
RAPGEF2HSPA1BIntAct20936779 details
RAPGEF2FBXW11BioGRID25332235 25515538 details
RAPGEF2BTRCBioGRID25332235 25515538 26091241 details
RAPGEF2UBCBioGRID25332235 details
RAPGEF2CTNNB1HPRD10873669 details
RAPGEF2PRKCIBioGRID, IntAct14676191 details
RAPGEF2YAP1BioGRID, IntAct24255178 24366813 30472188 details
RAPGEF2RACGAP1BioGRID, IntAct26496610 details
RAPGEF2TRMT6BioGRID, IntAct26496610 details
RAPGEF2MESDBioGRID, IntAct26496610 details
RAPGEF2UHRF1BP1BioGRID, IntAct26496610 details
RAPGEF2LRR1BioGRID, IntAct26496610 details
RAPGEF2ZNF512BBioGRID, IntAct26496610 details
RAPGEF2HTTBioGRID, IntAct26496610 details
RAPGEF2SREK1IP1BioGRID, IntAct26496610 details
RAPGEF2BDP1BioGRID, IntAct26496610 details
RAPGEF2ANO3BioGRID, IntAct26496610 details
RAPGEF2SEC62BioGRID, IntAct26496610 details
RAPGEF2ATP5MKBioGRID, IntAct26496610 details
RAPGEF2ERI3BioGRID, IntAct26496610 details
RAPGEF2COX5ABioGRID, IntAct26496610 details
RAPGEF2XIAPBioGRID, IntAct26496610 details
RAPGEF2SP140LBioGRID, IntAct26496610 details
RAPGEF2PRPSAP1BioGRID, IntAct26496610 details
RAPGEF2VPS50BioGRID, IntAct26496610 details
RAPGEF2H3-4BioGRID, IntAct30021884 details
RAPGEF2H1-5BioGRID, IntAct30021884 details
RAPGEF2WWOXBioGRID24550385 30619736 details
RAPGEF2EPB41L5BioGRID25332235 details
RAPGEF2KIF11BioGRID25332235 details
RAPGEF2PTPN13BioGRID25332235 details
RAPGEF2FLNCBioGRID25332235 details
RAPGEF2LMNABioGRID25332235 details
RAPGEF2SCYL2BioGRID25332235 details
RAPGEF2H4C15BioGRID25332235 details
RAPGEF2SND1BioGRID25332235 details
RAPGEF2KCTD17BioGRID25332235 details
RAPGEF2MAGI3BioGRID25332235 details
RAPGEF2ZNRD2BioGRID25332235 details
RAPGEF2STOMBioGRID25332235 details
RAPGEF2CTTNBP2BioGRID25332235 details
RAPGEF2KCTD5BioGRID25332235 details
RAPGEF2HMCN1BioGRID25332235 details
RAPGEF2PLECBioGRID25332235 details
RAPGEF2TJP1BioGRID25332235 details
RAPGEF2TTNBioGRID25332235 details
RAPGEF2LAP3BioGRID25332235 details
RAPGEF2SLC25A11BioGRID25332235 details
RAPGEF2TNKSBioGRID25332235 details
RAPGEF2VSIG8BioGRID25332235 details
RAPGEF2XPO1BioGRID26673895 details
RAPGEF2USP11BioGRID26496610 details
RAPGEF2WDR91BioGRID26496610 details
RAPGEF2SQSTM1BioGRID30581152 details
RAPGEF2BRD8BioGRID31753913 details
RAPGEF2TRIM25BioGRID29117863 details
RAPGEF2HNRNPLBioGRID28611215 details
RAPGEF2VIRMABioGRID29507755 details