Entity Details

Primary name LIPL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06858
EntryNameLIPL_HUMAN
FullNameLipoprotein lipase
TaxID9606
Evidenceevidence at protein level
Length475
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesLPL

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0004465 lipoprotein lipase activity
GO:0004620 phospholipase activity
GO:0004806 triglyceride lipase activity
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0008201 heparin binding
GO:0008970 phospholipase A1 activity
GO:0009409 response to cold
GO:0009617 response to bacterium
GO:0009749 response to glucose
GO:0009986 cell surface
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010884 positive regulation of lipid storage
GO:0010886 positive regulation of cholesterol storage
GO:0010890 positive regulation of sequestering of triglyceride
GO:0016042 lipid catabolic process
GO:0016298 lipase activity
GO:0017129 triglyceride binding
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0031670 cellular response to nutrient
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034185 apolipoprotein binding
GO:0034361 very-low-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0042493 response to drug
GO:0042627 chylomicron
GO:0042632 cholesterol homeostasis
GO:0042803 protein homodimerization activity
GO:0043395 heparan sulfate proteoglycan binding
GO:0043495 protein-membrane adaptor activity
GO:0045600 positive regulation of fat cell differentiation
GO:0050729 positive regulation of inflammatory response
GO:0051004 regulation of lipoprotein lipase activity
GO:0052739 phosphatidylserine 1-acylhydrolase activity
GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO:0055096 low-density lipoprotein particle mediated signaling
GO:0070328 triglyceride homeostasis
GO:0071398 cellular response to fatty acid
GO:0071813 lipoprotein particle binding
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR000734 Triacylglycerol lipase familyFamilyFamily
IPR001024 PLAT/LH2 domainDomainDomain
IPR002330 Lipoprotein lipaseFamilyFamily
IPR013818 Lipase/vitellogeninDomainDomain
IPR016272 Lipase, LIPH-typeFamilyFamily
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR033906 Lipase, N-terminalDomainDomain
IPR036392 PLAT/LH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
238600 OMIMHyperlipoproteinemia 1 (HLPP1)An autosomal recessive metabolic disorder characterized by defective breakdown of dietary fats, impaired clearance of chylomicrons from plasma causing the plasma to have a milky appearance, and severe hypertriglyceridemia. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis. The disease is caused by variants affecting the gene represented in this entry.
144250 OMIMHyperlipidemia, familial combined, 3 (FCHL3)A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease. FCHL3 inheritance is autosomal dominant. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB06439 TyloxapolDrugbanksmall molecule
DB09568 Omega-3-carboxylic acidsDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule
DB13928 SemaglutideDrugbanksmall molecule

Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
LIPL_HUMANCSN6_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANCE126_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANLC7L2_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANPTN4_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANASCC2_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANUBE2Z_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANRL18A_HUMANBioGRID, HPRD, IntAct16169070 details
LIPL_HUMANCCND1_HUMANBioGRID, IntAct21988832 details
LIPL_HUMANSORT_HUMANbhf-ucl10085125 details
LIPL_HUMANHDBP1_HUMANbhf-ucl, UniProt20124439 30559189 details
LIPL_HUMANAPOA5_HUMANbhf-ucl15178420 details
LIPL_HUMANANGL4_HUMANUniProt19318355 details
LIPL_HUMANANGL3_HUMANUniProt19318355 details
LIPL_HUMANNDKM_HUMANIntAct32814053 details
LIPL_HUMANCCD26_HUMANIntAct32814053 details
LIPL_HUMANT185A_HUMANIntAct32814053 details
LIPL_HUMANSLN12_HUMANIntAct32814053 details
LIPL_HUMANPSMD9_HUMANIntAct32814053 details
LIPL_HUMANTGON2_HUMANIntAct32814053 details
LIPL_HUMANANM5_HUMANIntAct32814053 details
LIPL_HUMANEI2BD_HUMANIntAct32814053 details
LIPL_HUMANSNX12_HUMANIntAct32814053 details
LIPL_HUMANVKORL_HUMANIntAct32814053 details
LIPL_HUMANEMD_HUMANBioGRID12755701 details
LIPL_HUMANLRP2_HUMANBioGRID, HPRD7686151 details
LIPL_HUMANVLDLR_HUMANBioGRID, HPRD7592875 details
LIPL_HUMANLRP1_HUMANBioGRID, HPRD1281473 7510694 7989348 details
LIPL_HUMANA4_HUMANBioGRID21832049 details
LIPL_HUMANLIPL_HUMANBioGRID, HPRD12740382 14570890 details
LIPL_HUMANT22D2_HUMANBioGRID27337956 details
LIPL_HUMANCALR_HUMANBioGRID, HPRD12740382 details
LIPL_HUMANLMF1_HUMANBioGRID19783858 details
LIPL_HUMANAPOC2_HUMANHPRD10727238 11579204 details
LIPL_HUMANCETP_HUMANHPRD9374130 details